Yes. By a long shot.
The 100's are the Flagship speaker -- top of the line. They are the best speaker that Paradigm produces and they sound incredible. The 60's -- even the 80's -- really aren't any match for the Studio 100's.
However, they are power hungry, so if you do decide to get them, be sure and get an amplifier that is at least 200wpc or Bi-amp them with 2 amps of at least 100wpc. The 100's sound great, but they reach another level entirely when you feed them enough power.
I find the difference to only be in the base extension. This is based on demoing the entire Studio line for a couple hours total on two separate ocassions. I could have missed something though.
I noticed one difference listed in the specs is that the crossovers between the 60s & 100s occur at different frequencies. Can anyone explain how this might impact the sound?
i haven't listened to them both in comparison a lot, but to me, the 100's just sounded far more open and revealing than the 60's. i'm assuming this is because the 100's are a true three-way speaker, while the 60's are a two and a half. and probably the difference in crossover points that joe mentioned.
As mentioned above, the 100's are far better with bass extension(as you'd expect), but due to their 3-way design, midrange is MUCH smoother and sound is far more revealing and open. To me, the 60's always sounded strained in the mids. With the 100's, sound is smooth from top to bottom and soundstage is far superior to the 60's.
Joe, it looked to me like you got some good feedback. What else are you looking for?
BTW, if you are going to buy or already have a nice subwoofer, you might consider the 40s or 60s instead of the 100s--especially if you don't have a high-power amp to drive the 100s.