Though not so pervasive in the language, and I don't know if that was originally from Buckaroo Banzai, but it gets on my nerves. Sounds like a Yogi Bera quote, but it still gets to me.
I like Seinfeld but I also despise that saying along with "Heloooooooo." Both expressions were not particularly memorable but were marketed as 'classic' lines by NBC's promos. People were ready to use them before they even saw the episodes they were featured in. Ironically, Jerry Seinfeld often has pointed out his disgust for catch phrases like "don't go there."