cable boxes are notorious for introducing hum. Make sure you rg6 coming into the house is grounded. also check all of your coax connections to make sure the connectors are tight. Check this PDF out. it is an outline from a CEDIA class i took on ground loops...
try putting the isolater inline and see if it works. no need to combine the pair, just use one side (red or white). if it works- great! if not, back to the drawing board. nothing bad will happen by just trying it. i took a CEDIA class on ground loops, so I have some class info stashed...