Lost.
Lost went from being probably one of the last big appointment shows for a lot of people, to virtually forgotten because the ending made it clear they were just making this crap up as they went along and didn't deliver a satisfying conclusion to the mystery.
Personally, my example is Life...
"New, now, serialized, short, and streaming" also means no show will ever have the impact of even a Network failure ever again.
Manimal, Supertrain, Cop Rock, those are still referenced for being huge failures. But the majority of even successful "prestige" TV shows of the streaming era won't...