Well, the system may not boot with that configuation but it's hard to say as it depends on your BIOS. If the system is expecting to boot from the primary hard drive then all it will find is a new (empty) drive. It may, however, figure out that it there's nothing on the first drive to boot from...
Jon, the thumbnails may load slowly, it just depends on how large the actual file is. I have a lot of 2400dpi scans of 35mm negs on my system and the .bmp files are about 20-25mb each. Extracting the thumbnail does take Windows a good few seconds intially. Couple of things - there is an...