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Yes, this movie is based on a novel and it is a fictionalized version of her life. The 2001 CBS miniseries carried the following disclaimer at the beginning:

I think she looks closer to Marilyn than any of the other actresses that have played her and that includes Poppy Montgomery in the original CBS miniseries version of "Blonde" (2001). This film is the second adaptation of Joyce Carol Oates' best seller.