I didn't skip Season 1, but I will be skipping the complete series. I liked the show a lot when it was broadcast, but found in viewing Season 1 (which, by the way, did look great) that it was nowhere near as good as I remembered it. I eventually gave Season 1 away.
Cannon, on the other hand...
I believe the original CBS release of Season 1 had both halves of the Barnaby pilot. I suspect the complete set will also. Why Cannon has the abbreviated version, who knows?
In for Cannon, maybe Matt Houston. Barnaby Jones was always time-passer for me, so the S1 release already out is all I need. Evan at that, I was surprised at how poorly it held up for me, as I thought it was a better show than that. Memory can fool you. As for the rest, meh. But if they float...