The mouse works wonderfully on my Macbook Pro. I was actually able to go into the Logitech Control Center and assign it specific search functions. I press a button and GOOGLE or YAHOO search comes up. I can also program it if I wish to bring up FINDER. I found the mouse to be very responsive on an ordinary tabletop taking away the need to have a mouse pad. The scroll wheel works extremely well. A simple roll of the wheel can get you from top to bottom of page in seconds. Also a huge plus is the fact that this mouse automatically powers itself off when not in use. The only thing missing here is a travel pouch. For some reason I had thought one would be included. Despite the fact there was none, I was able to neatly pack the mouse in my laptop bag. I have owned a wide array of Logitech products including their top-of-the line keyboards, webcams and mice. None of them have worked perfectly with Mac. Logitech is just not a mac-friendly company. This is the very first product I have bought from them that actually works perfectly under OS X. I highly recommend the Logitech VX Nano for anyone that wishes to ditch their trackpad for the comfort of a mouse.