Yeah, I use my HTPC to run REW and other calibration software.
You are correct that you'll need the MIniDSP 2x4 HD. This is the specific video guide that walks you through the process of sub EQ - it's very comprehensive:
Thanks again Dave. This also might be a step into a better/more up to date method for playing HD audio. Now that Oppo has gone away and their app no longer functions, I've lost my method of controlling playback. So, a Mac Mini might find a permanent home in the HT.