Home Theater Forum Cancer Research Team (1 Viewer)

[Edwin-S]

Okay. Thanks for the instructions and replies. I'm going to modify the profile.

 

[Henry Carmona]

Its been a while, but im back to promote our team.
Just want to say hi to everyone and am wondering if you guys are still donating your computer time for research.
And also hoping to get some new members

 

[Rob Gardiner]

Joined!

Between my office, my home, and my downstairs neighbors, I should be able to add somewhere between 5 and 10 PCs to the effort.

 

[SethH]

I just signed up. Thanks for bringing this back up. I used to have this software on my computer 3 or 4 reformats ago, but was never on a team. This is great!

 

[Greg*go]

Funny, I just looked up the HTF team yesterday and saw you were all slacking a bit It's good to see this subject brought back up!!

 

[Henry Carmona]

Thats Great!

Thanks Rob, Seth, & Greg. Although there are different ways to contribute in the search for new drugs and a cure, i think this is a simple way to help and anyone with a PC can do it.

Things, and life, take on a much deeper meaning when you have a loved one die from cancer.

For those interested, heres just a little new from last November:

November 16, 2004

The project continues to be an extraordinary success with the milestone of three million PCs being involved likely to be achieved early in 2005. The initial project screened 3.5 billion drug-like molecules against 12 cancer targets, and since that time two more have been added.

That initial phase produced a vast number of hits, far more indeed than could be synthesized and tested. In order to make progress, Phase 2 of the project took those hit molecules and treated them with the more sophisticated LigandFit software from the Accelrys company. The screensaver was used to run calculations using LigandFit whereby the binding energy between the small drug-like molecule and the protein target is calculated. The more tightly the molecule binds to the target, the more useful it is likely to prove as a drug (since tight binding goes hand in hand with a low dose and lower likelihood of side effects).

Even after this stage we have a large number of hits, and these have had to be brought to a more tractable number by manual consideration of individual molecules.

We have taken one particular target, the phosphatase, and prepared a list of some 400 compounds which the Inhibox company (set up to exploit the results and in large part owned by the NFCR and the University of Oxford) has purchased and had synthesized. Those compounds have now been commercially screened in the laboratory and between 2-4% of them do show activity. This percentage of genuine hits is very encouraging since the pharmaceutical industry might typically expect rather less than 0.1% of hits to emerge from in silico screening. With that particular series of compounds the next step is to persuade pharmaceutical or biotechnology companies to take up these experimentally verified hits and to test them further.

This process has taken longer than we hoped and we are conscious that we have a lot of data that could be used by other people. We are contemplating ways in which we might pass on this data without damaging potential patent protection, without which no company would ever invest the funds required for the extensive biological testing.

 

[Henry Carmona]

Just my yearly bump
Hope to get more invovled.

 

[Henry Carmona]

A years too long, i think i need to bump this monthly.

God Bless

 

[Henry Carmona]

*bump*

 

[Ken Chui]

I just signed up.

 

[Henry Carmona]

AWESOME to have u join up Ken!

 

[Henry Carmona]

*Bump*

 

[Richard Travale]

I just downloaded the program and joined the team as well.

 

[Henry Carmona]

Thats great! Welcome Richard

 

[Henry Carmona]

Bump
Sorry, i accidentally bumped the wrong thread earlier.
But glad we got our 33rd member
Wow! Already 5yrs

 

[Henry Carmona]

*Bump*

 

[Henry Carmona]

*bump for April*

 

[Henry Carmona]

November bump

 

[Henry Carmona]

Its been a long time, heres a bump

 

[PS Nystrom]

Count me in as another Mac user who would jump at the chance to offer my computer.
Thank you,
Pieter

Still no Mac version?