No to be honest. Tonally very similar. The M80TiSe will have appreciably deeper bass if you are not using a subwoofer but their real strength is the levels that they are capable of. The M80TiSe can play very loud while staying open and clear sounding. In a direct A/B comparison, the M60TiSe have a sharper focus on the stereo imaging. The four ohm load of the M80TiSe is fine with most receivers. Out of my clientel, only one person has had a problem with the receiver shutting down. In that case, Axiom graciously manufactured an impedance matching box for the client to solve that.