I don't get the sense that Peter or Ned knew Zendaya's MJ before Homecoming. But definitely Ned, Betty, and Liz should be in the mix.
There's probably an interesting story to be told covering the period from when the MCU Peter gets bit by the spider through when his Spider-Man comes onto Tony...
The TV rights for Spider-Man are very messy. The contractual status as of 2014 leaked back when everything else was leaking out of Sony. Sony had the rights to:
Develop and produce live action or animated theatrical motion pictures
Live-action television series
Animated television series with...
When we met the MCU's version of Spider-Man in Civil War, he had already been at it a while. The Homecoming trilogy of movies covers his sophomore, junior, and senior years of high school. This new animated series fills in the gaps, covering the origin story of the MCU's Spider-Man from getting...