As long as the subwoofer, regardless of how large it is, can reach as high as the crossover setting they should work together. The F12 has a frequency response of 25-200hz so a crossover of 120 or 150 would work (100 might be too low for the Nanosats). Blending the two isn't the problem but having the subwoofer play that high is the drawback of small satellite speakers. But sometimes compromises have to be made. Hopefully you can position the sub close to the front speakers and far away from you. This will at least help a little to reduce the localization of the sub.
Just for fun I've set the crassover as high as 200hz (the upper limit of my 10" sub) and for the most part it was acceptable but there were times when the location of the subwoofer was very noticable. But 100 (with very capable front speakers) is the highest I like to set a crossover. Some prefer 80, others say 120 and let the sub do most of the work.
An MBM would be a great idea. But I really don't know much about them and it would add considerably to the cost.
Edited by gene c, August 17 2013 - 08:08 PM.
"Everyday room": Panasonic 58" Plasma, Dish HD DVR, Pioneer Elite vsx-23, BDP-23 BR, dv58avi universal dvd player, Dynaudio Audience 50's, 40's 122C, Dayton HSU-10 subwoofer.
"Movie/Music room": Toshiba 65" DLP, Dish HD receiver, Adcom GF-700 5.1 receiver, OPPO BDP-80 BR player, Polk LSI25's-LSi7's-LSiC, 2 original Dayton 10" "Mighty-Mites" subwoofers. (subject to change without notice).
Also have...too much to list. Help me.