I gotta go with the Whitestar from Babylon 5. Not too big, not too small, very fast, powerful, and can jump into hyperspace on its own, self-repairing.
Of course I would need someone to translate my orders into Minbari.
For runs around the local stars I would want the Millenium Falcon but I'd put it into my local 'Space Toys" Dock to add some upgrades. A Holodeck closet, and Replicator. Then I'd run it over to "Monster Garage Dock" to have some customization, - creating a saucer section which could separate from the star drive section. Just in case all that wacking on it (with hand or wrench) during emergenices did not get the thing running again, on more persnickety days.
For long treks,I would use a transporter, not being fond of losing all those years in cryo. Making sure the Transporter was equipped with good insecticide.