I never thought I'd find myself typing these words, but I'm trying to help my mother-in-law. About 15 years ago she developed the following symptom. She would wake up during the night with numbness and/or tingling in her hands. The sensation was relatively mild and would disperse in a few minutes, but it was an irritation. At the time she was employed as a secretary and did a large amount of typing. Over the last fifteen years the symptoms have remained but over the last year or so they have worsened considerably so that it is a rare night when she gets uninterrupted sleep. Okay, now before you say the words 'carpal tunnel syndrome' the symptoms don't entirely fit: (a) there's no Tinel's or Phelan's sign (b) the symptoms only appear during sleep To exclude the other obvious possibility - it is *not* the result of her lying on her hands and them going numb. The numbness is like glove anaesthesia (i.e. the whole hand is numb, not just half of it). This is typically a psychosomatic sign, but I can promise you in this case it isn't (trust me, I'm a psychology prof! But seriously, there's a lengthy set of reasons why it isn't that I don't want to get into because it would just sidetrack things). There is no sign of damage to the neck, spinal column, arms, or similar. My mother-in-law has been seen by an osteopath, of course by her medical general practitioner, by a surgeon specialising in hands, and by a neurologist, and has had all obvious tests done. The current medical diagnosis is basically carpal tunnel syndrome-ish, but nobody is certain. Has anyone encountered this phenomenon before, please? It's not that my mother-in-law is seriously ill, but if we can nail the problem it would perhaps mean she could get a decent night's sleep. Incidentally, she's now in her late sixties, physically very fit, doesn't drink or smoke (never has done) has no vices and is not on any medication. She stopped doing secretarial work about eight years ago, and in any case the level of her physical activity appears unrelated to the symptoms.