I'd say, if it makes an audible difference to you when using only one sub, then go for two!

If you can, though, maybe budget yourself around $300-350 per sub and get something from Dayton, or Lava Sub, or ED, or HSU maybe? From what you've said about the Klipsch sub, it's clear your not impressed, and if nothing else, the subwoofer component of any system should impress you. If you think the Klipsch subs will be fine for your needs, then stick with them!
As per the question about using the P300HDs, I'm having a hard time imagining that four subs would do you any good in a room that size because the front subs will bounce sound off the back wall with enough power remaining to make the rear reflex of the room audible. If you set up your front Klipsch (or whatever you go with) subs in the right position, then extra subs in the back (especially different brand subs) might clash frequencies near the middle of the room and really hurt the soundstage of your system in the lower range. I've experienced this in a friends apartment and it sounds terrible, audibly terrible. I really think a couple of good subs in the front will satisfy your need for linear sound.

With regards to the comment about experience and wisdom and all that, really it's about how much time you're willing to spend simply learning the trade of crafting HT systems, not about how many systems you've built in your day. If you have the motivation to get what you want and KNOW what it is that you want, you will achieve it!

I personally have only built ONE basic system, but took about six months of research to do so. But I understand enough about sound reproduction and speakers to give what little advice I can about some lower end to mid range speakers and subs. Stick with it and you too will get more and more comfortable and knowledgable about sound.
P.S. Sooner or later, like me, you might even get into DIY subs and speakers and then really gain significant knowledge about this stuff (haha). I felt like I was starting from the beginning again when I ventured into DIY speakers.