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  • "Go for the eyes, Boo, go for the eyes!"
    —Minsc, from Baldur's Gate II giving instructions to his imaginary friend during battle

  • "Oh, I get it. Let's play with the old man's head, is it? He's half-senile, he'll forget I said anything! Wait uh, what was this about, anyway?"
    —Jolee Bindo, from Star Wars: Knights of the Old Republic during one of his rambling story sessions.

  • Harold: "Mutants. They were everywhere. Seems you couldn't fart without hitting one. They were coming Mostly from the Northwest, though."
    Vault Dweller: "You farted Northwest?"
    Fallout

  • "You're so cute when you're bleeding!"
    —the orc female Gryshka, from World of Warcraft in a love letter to her sweetie

  • "I apologize profusely for any inconvenience my murderous rampage may have caused."
    —random gnome female joke, from World of Warcraft

  • "Leeroy Jenkins!"
    —Leeroy Jenkins, from World of Warcraft

OK, so what are your favorites?