I doubt it. Remember that it's been established on the show that the Prime Universe and the Mirror Universe finally temporally diverged far enough apart circa the 27th Century that it's now impossible to cross over (and which nearly killed Mirror Georgiou before she used the Guardian of Forever...
^ Also, shows like Jericho, 30 Rock, Dexter, and Studio 60 on the Sunset Strip premiered alongside Heroes (plus the aforementioned LOST and BSG), and I had one of the most-packed "appointment" fall seasons in years during that time.
^ Also, Fallout 2 covers northern Nevada (New Reno), plus you can return to southern California and revisit several locations from Fallout 1 (including Vault 13).