I like the names being thown around for the leads. I thought Matt Damon for sure as Kirk, Gary Sinise is perfect for McCoy (look and voice), Zachary Quinto does resemble Leonard Nimoy. I thought of Russell Wong for Spock, looks like they wouldn't have to do much with the ears:
Romeo Must Die. James McAvoy as Scotty? Might be nice to have a real Scotsman in the role.