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Theoretically, long signal runs are supposed to be better than long speaker cables, but practically speaking I doubt you’d be able to tell the difference one way or the other. Especially the distance you’re talking about here – 22 ft. isn’t terribly long for either signal or speaker cable.
Personally I prefer to have all the equipment together, but that’s just me.
Which raises another issue: Putting equipment at different places around the room will probably put them on different circuits (unless you already have dedicated circuits run). Sometimes this can cause ground loops.
Since you have all the necessary cabling, it would be easy for you to try it both ways and draw your own conclusions.
Regards,
Wayne A. Pflughaupt
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